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Career Development Core

Craig Marcus, PhD

Nancy Kerkvliet, PhD

Anna Harding, PhD

The Environmental Health Sciences Center supports faculty members with strong interests in environmental hgealth science reserarch and outreach.  The Career Development Core helps faculty develop strong programs and build effective networks to become leaders in the environmental health field.  The core will enable and energize new faculty to coalesce into teams that will develop novel approaches to address the strategic goals of NIEHS.

The Core has a network of Center members and other experts across the OSU campus to serve as mentors and potential collaborators.  Our professional networks also include other Environmental Health Sciences Centers and NIEHS funded groups.

Research efforts of new investigators can be supported by the Career Development Core.  There are also pilot project opportunities.

 

Career Development Leadership

Dr. Craig Marcus, Professor and Head of the Department of Environmental and Molecular Toxicology.

Dr. Nancy Kerkvliet, Professor of Environmental and Molecular Toxicology.

Dr. Anna Harding, Professor and Co-Director of the School of Biological and Population Health Sciences.

 

 

Graduate and Postdoctoral Training Program Overview

EHSC faculty, staff, and core units assist in the recruitment and training of promising individuals to levels in toxicology and environmental health that can effectively meet the growing global challenge.

The Training Programs, with their hands-on interdisciplinary research opportunities and complementary academics, are integral to providing vital graduate and postdoctoral training at OSU.

Former graduates hold professional positions in government, academia, and industry.

CONTACT

Robert Tanguay, Professor
Director of the NIEHS Toxicology Training Grant
Phone: 541-737-6514
Fax: 541-737-7966
robert.tanguay@oregonstate.edu

OPPORTUNITIES

Highlights of Current and Past Trainees

NIEHS Training Grant in Toxicology

 Oregon State University (OSU) offers interdisciplinary training in toxicology through its predoctoral degree program in the Department of Environmental and Molecular Toxicology and through postdoctoral fellowships. The NIEHS Training Grant offers financial support and provides unique research opportunities to selected predoctoral candidates and postdoctoral fellows. Support is available on a competitive basis to applicants with a B.S., M.S., or Ph.D. in chemistry, biochemistry, pharmacology, toxicology, or the biological sciences.

A limited number of graduate fellowships are also available through the Linus Pauling Institute.

Training Grant Faculty

Affiliated faculty members provide challenging basic sciences academics while mentoring students as they develop individual projects; this intensive course of studies leads to the M.S. or Ph.D. degree in toxicology. Training is provided in diverse areas including analytical, aquatic, biochemical, comparative, environmental and molecular toxicology with an emphasis on a mechanistic approach. Research projects focus on some aspect of toxicology or environmental health.

Training Faculty Member Research Interests
Robert L. Tanguay, Ph.D., Prof., EMT, OSU Exploit the zebrafish model to study the mechanisms by which environmental exposures produce biological responses. Understand individual susceptibilities to environmental insults. Discover the molecular pathways that prevent or promote vertebrate tissue regeneration. Define the characteristics of nanomaterials that dictate biological responses.
Paula Amato, M.D., Assoc. Prof
OB GYN, OHSU
Specializes in treating patients with infertility, menopausal issues, and reproductive endocrine disorders such as polycystic ovary syndrome and endometriosis and is trying to understand the role of environmental exposures on these diseases.
Kim Anderson, Ph.D., Prof.,
EMT, OSU
Develop bioanalytical technologies to determine bioaccessability and to measure actual environmental exposure dose to humans. Develop and evaluate new bioanalytical tools to determine bioaccessable contaminants in air, water and soils.
Joseph S. Beckman, Ph.D., Prof., Biochemistry and Biophysics, LPI Elucidate the role of oxidative and nitrative stress in amyotrophic lateral sclerosis. Investigate the role of lead in ALS (which curiously is protective). 
Roderick Dashwood, Ph.D., Professor, EMT, LPI, OSU Elucidate the molecular and biochemical events associated with the development of colorectal cancer (CRC). Investigate preliminary results suggesting that chlorophylls (in green, leafy vegetables) and tea polyphenols might be effective in reducing the risk from CRC. Study dietary phytochemicals as histone deacetylase (HDAC) inhibitors, which may act as cancer chemopreventive as well as chemotherapeutic agents. 
Jennifer A. Field, Ph.D., Professor, EMT, OSU Develop and apply sensitive and selective analytical methods to quantify illicit and legal drugs and human urinary biomarkers in municipal wastewater. Collaborate with drug epidemiologists to determine the complementarity of wastewater measurements and traditional measures of drug abuse.
Balz Frei, Ph.D., Director, LPI, OSU Study the mechanisms of atherosclerosis and the modulatory effects of antioxidants, essential minerals, and micronutrients. Investigate the mechanisms and consequences of endothelial dysfunction, the role of pro-oxidant transition metal ions such as iron and copper in this process, and the effectiveness of vitamin C, lipoic acid, and flavonoids in ameliorating endothelial dysfunction. Find new, effective strategies to prevent or treat heart disease and stroke by dietary means or supplements.
Allison Fryer, Ph.D., Dept. of Physiology & Pharmacology, OHSU A major feature of asthma is eosinophils in the lungs. Fryer and her trainees have demonstrated that parasympathetic nerves in the lung are actively engaged in recruiting eosinophils to nerves via expression of chemotactic factors and adhesion molecules. They are investigating regulation of these signals. New data suggest that eosinophils have additional roles, important in modulating peripheral nerve function. They are investigating the role of eosinophils in nerve repair and plasticity.
Tory M. Hagen, Ph.D., Prof., Biochemistry and Biophysics, LPI, OSU Understand the basic biochemical mechanisms of aging and the ways in which micronutrients may promote health in the elderly. Identify precise gene-nutrient interactions that improve xenobiotic and oxidative stress response, which otherwise markedly declines in the elderly. Translate the knowledge gained in rodent models of aging toward developing strategies that may prolong human “healthspan”—the time of life full of vitality and free of disease.
Stacey Harper, Ph.D.
Asst. Prof., EMT, OSU;
Harper and her lab investigate the environmental, health and safety impacts of nanotechnology in order to support the responsible development of this rapidly growing industry. Our current lack of information on the environmental fate and toxic potential of nanomaterials prohibits us from performing valid risk assessments. Issues of particle behavior, bioavailability and toxicity are central to quantitative risk assessment. Studies in the Harper laboratory are designed to effectively improve our understanding of how and why nanomaterials interact with and sometimes alter living systems.
Emily Ho, Ph.D.
Assoc. Prof. of Nutrition and Exercise Sciences, OSU, LPI
Elucidate the molecular mechanisms by which environmental alterations in nutrient status affects the initiation and/or progression of chronic disease states such as cancer. Identify molecular mechanisms by which zinc acts as an antioxidant and protects us from environmental challenges. Investigate soy, teas and cruciferous vegetables that have antioxidant, anti-inflammatory and anti-proliferative properties on limiting prostate cancer development. Understand the interaction between diet, epigenetic alterations in histone structure, and prostate cancer risk.
Arup Indra, Ph.D
Associate Prof. of Pharmacology, OSU
Identify the mechanism(s) of signal transduction between keratinocytes and melanocytes that contributes to the development of deadly melanoma. Develop novel therapeutic strategies for preventing and treating this cancer. Explore alternative medicine such as xanthohumol (XN), the principal prenylated flavonoid in beer hops (Humulus lupulus L.), for preventing and curing inflammatory skin disease and cancers resulting from environmental insults.
Nancy I. Kerkvliet, Ph.D., Professor, EMT, OSU Understand the mechanisms by which chemicals of environmental significance interact with the immune system. Focus on chemicals that act as ligands for the Ah receptor (AhR), a transcription factor that alters gene expression. Map the pathways of AHR signaling in T cells as they respond to different antigenic stimuli. Identify new possibilities for immunosuppressive therapies in the treatment of autoimmune disease.
Siva Kolluri, Ph.D.
Assoc. Professor, EMT, OSU
Elucidate the signaling of ligand-activated transcription factors such as aryl hydrocarbon receptor (AhR) in mediating proliferation and differentiation of different human cells upon exposure to dioxins and other PAHs. Develop nuclear receptor-based therapeutics for preventing and treating cancer. Identify pathways that disrupt hypoxia signaling in cancer cells in order to develop novel cancer therapeutics.
Amanda McCullough, PhD., Asst. Prof., Molecular and Medical Genetics, OHSU Elucidate the biochemical mechanisms of DNA base excision repair systems and the regulation and roles of DNA repair in cellular responses to environmental stress. Correlate alterations in these systems with human diseases, cancers, and aging. Study two distinct DNA repair processes: 1) mechanisms and regulation of human oxidative DNA damage-specific repair and 2) biochemical mechanisms and therapeutic applications of ultraviolet (UV) light-induced DNA damage-specific glycosylases.
Jacob Raber, Ph.D.
Asst. Prof., Depts. of Behavioral Neuroscience and Neurology, OHSU
Study mouse models and children to determine how exposure of the developing brain to methamphetamine effects brain function in adulthood. Elucidate the role of genetic and environmental factors in brain function. Develop therapeutic intervention to prevent or even reverse impairments in brain function.
Stephen Lloyd, Ph.D.
Senior Scientist, CROET, OHSU
Conduct studies in 1) DNA repair, 2) molecular mechanisms of mutagenesis and carcinogenesis, and 3) the relationship between compromised DNA repair and the metabolic syndrome. Study the enzymes that initiate DNA base excision repair of UV light- and oxidative stress-induced DNA damage. Elucidate the mechanisms by which DNA carcinogens produce mutations.
Staci Simonich, Ph.D., Professor, EMT, OSU Study human exposure to new persistent, bioaccumulative, and toxic pollutants used in consumer products, including polybrominated diphenyl ether flame retardants. Study the exposure of Chinese citizens to substituted and unsubstituted polycyclic aromatic hydrocarbons via particulate matter. Develop new analytical chemistry methods to identify and quantify environmental pollutants, human and environmental exposure pathways, and human and environmental risk assessment. 
Daniel Sudakin, MD, Assoc. Prof., EMT, OSU Interests include the human health implications of environmental exposure to environmental chemicals and mycotoxins. Currently focused on the clinical toxicology of two agriculturally important mycotoxins, aflatoxins and trichothecenes. Another project involves the societal implications of methamphetamines use in rural Oregon.
Mitchell S. Turker, Ph.D., CROET, OHSU Elucidate interactions between environmental exposures and the mammalian genome. Examine the types of mutations that occur spontaneously in mouse tissues and that are induced in vivo by different forms of ionizing radiation. Examine pathways of epigenetic silencing in mammalian cells. Study the relation between environmental gene repression and induction of gene silencing.
David E. Williams, Ph.D., Prof., EMT, OSU; Adjunct Prof., Physiology and Pharmacology, OHSU Study the metabolism of environmental chemicals and prescription and recreational drugs. Exploit the rainbow trout as a cancer model to conduct dose-response studies at ultra-low carcinogen doses in order to enhance the data set used for human risk assessment. Investigate the role of dietary micronutrients in the prevention of cancer.