TitleThe Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes.
Publication TypeJournal Article
Year of Publication2023
AuthorsGosline, SJC, Kim, DNam, Pande, P, Thomas, DG, Truong, L, Hoffman, P, Barton, M, Loftus, J, Moran, A, Hampton, S, Dowson, S, Franklin, L, Degnan, D, Anderson, L, Thessen, A, Tanguay, RL, Anderson, KA, Waters, KM
JournalSci Data
Volume10
Issue1
Pagination151
Date Published2023 Mar 21
ISSN2052-4463
KeywordsAnimals, Environmental Exposure, Hazardous Substances, Humans, Northwestern United States, Polycyclic Aromatic Hydrocarbons, Zebrafish
Abstract

The OSU/PNNL Superfund Research Program (SRP) represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons (PAHs) at various superfund sites in the Pacific Northwest and assess their potential impact on human health. To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental toxicity model that provides quantitative measurements of the exposure to chemicals. Toward this end, we have linked over 150 PAHs found at Superfund sites to the effect of these same chemicals in zebrafish, creating a rich dataset that links environmental exposure to biological response. To quantify this response, we have implemented a dose-response modelling pipeline to calculate benchmark dose parameters which enable potency comparison across over 500 chemicals and 12 of the phenotypes measured in zebrafish. We provide a rich dataset for download and analysis as well as a web portal that provides public access to this dataset via an interactive web site designed to support exploration and re-use of these data by the scientific community at http://srp.pnnl.gov .

DOI10.1038/s41597-023-02021-5
Alternate JournalSci Data
PubMed ID36944655
PubMed Central IDPMC10030892
Grant ListP42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States
P42 ES016465 / ES / NIEHS NIH HHS / United States