| Title | Reduced interferon gamma production by antigen-stimulated cord blood mononuclear cells is a risk factor of allergic disorders--6-year follow-up study. |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Kondo, N, Kobayashi, Y, Shinoda, S, Takenaka, R, Teramoto, T, Kaneko, H, Fukao, T, Matsui, E, Kasahara, K, Yokoyama, Y |
| Journal | Clin Exp Allergy |
| Volume | 28 |
| Issue | 11 |
| Pagination | 1340-4 |
| Date Published | 1998 Nov |
| ISSN | 0954-7894 |
| Keywords | Antigens, Asthma, Child, Child, Preschool, Dermatitis, Atopic, Fetal Blood, Follow-Up Studies, Humans, Hypersensitivity, Immunoglobulin E, Infant, Infant, Newborn, Interferon-gamma, Interleukin-2, Leukocytes, Mononuclear, Rhinitis, Allergic, Seasonal, Risk Factors, Statistics as Topic, Time Factors |
| Abstract | BACKGROUND: It is not sufficient to predict 'high allergic risk newborns' on the basis of increased IgE concentrations of cord blood alone, because a raised cord blood IgE concentration is specific but not sensitive in the prediction of the development of allergic disorders. Warner et al. have reported that interferon gamma (IFN-gamma) production by allergen-triggered cord blood cells is a predictor of atopic eczema, based on the 1-year follow-up study. OBJECTIVE: We examined whether IFN-gamma production by antigen-stimulated cord blood mononuclear cells (CBMCs) is a risk factor of allergic disorders, based on the 6-year follow-up study. METHODS: The relationships among cord blood IgE concentrations, IFN-gamma and interleukin-2 (IL-2) productions by antigen-stimulated CBMCs, and the development of allergic disorders in 21 infants for 6 years were investigated. RESULTS: Atopic dermatitis, atopic dermatitis and allergic rhinitis, or atopic dermatitis and bronchial asthma developed in seven of 21 subjects. The maximal IFN-gamma concentration in culture supernatants of ovalbumin (OA) or bovine serum albumin (BSA) stimulated CBMCs in infants who developed allergic disorders was significantly lower (P < 0.01) than that in infants who did not develop any allergic disorders. In contrast, the maximal IL-2 concentration in culture supernatants of OA- or BSA-stimulated CBMCs in infants who developed allergic disorders was not lower than in infants who did not develop any allergic disorders. Moreover, the IFN-gamma concentrations were negatively correlated with cord blood IgE concentrations. CONCLUSION: Reduced IFN-gamma production by antigen-stimulated CBMCs is a risk factor of allergic disorders. |
| DOI | 10.1046/j.1365-2222.1998.00418.x |
| Alternate Journal | Clin Exp Allergy |
| PubMed ID | 9824405 |
