• Friday, August 5, 2022

    1:00-2:00 PM
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    Amazon Prime for Inflammation - NLRP3 Inflammasome Activation Mechanism

    Reginald McNulty
    Assistant Professor
    Department of Molecular Biology and Biochemistry, The University of California Irvine

    The NLRP3 inflammasome has been identified as a key immune sensor for tissue damage. Although NLRP3 inflammasome assembly/activation leads to the production of inflammatory messengers (called cytokines) that alert the host immune system to initiate inflammatory responses, its dysregulation often results in overt diseases due to uncontrolled inflammation. Unfortunately, exposure to a number of environmental toxicants including PFAS have been shown to induce NLRP3 inflammasome activation that in turn initiates an undesirable inflammatory response, thereby causing numerous pathologies. Although stimulating agents have not been demonstrated to directly bind NLRP3, they are able to trigger mitochondrial damage and subsequent release of mitochondrial contents that somehow signal the activation of NLRP3 inflammasome. We seek to identify the mitochondrial ligand responsible for direct NLRP3 activation and probe the molecular determinants of recognition for this interaction.

  • Friday, July 1, 2022

    11:00am - 12:00pm (PST)
    TBD

    Darryl Hood

    Ohio State University
  • Friday, June 3, 2022

    11:00am - 12:00pm (PST)
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    SBIR/STTR Opportunities Workshop

    .


    11:00:00 AM: Introduction Robyn Tanguay
    11:05:00 AM: Basics of NIEHS SBIR and STTR programs NIEHS
           ES priority areas and success stories
           Example Programs NIEHS
           Basic Program Requirements
    Company Example #1 (OSU Faculty member)  Steven O’Connell
    MyExposome
    Company Example #2  Roarke Horstmeyer
           (Company working with OSU Faculty member)  Ramona Optics
    How can State of Oregon and OSU help?  Karl Mundorff
    Panel Discussion and Q/A  All

     

    NIEHS:
    Daniel T. Shaughnessy, Ph.D.
    Health Scientist Administrator
    Tel 984-287-3321
    [email protected]
    MyExposome, Inc.:
    Steven O'Connell, MS PhD
    Senior Scientist/Co-founder
    Corvallis, OR 97330
    www.myexposome.com
    Lingamanaidu V. Ravichandran, Ph.D.
    Health Scientist Administrator
    Tel 984-287-3309
    [email protected]
    Ramona Optics:
    Roarke Horstmeyer, PhD
    1000 W. Main St., Ste 2A
    Durham, NC 27701
    www.ramonaoptics.com
    OSU:
    Karl Mundorff
    Executive Director of Innovation and Entrepreneurship, Director OSU Advantage
    Accelerator
    [email protected]

     

  • Friday, May 6, 2022

    11:00am - 12:00pm (PST)
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    Basic Principles Of Human Health Risk Assessment For Environmental Chemical Mixtures With A Focus On Estimating Risks From Hydrocarbon Mixtures

    Margaret Pratt
    Center for Public Health and Environmental Assessment
    US EPA

    Chemical risk assessments follow a multistep paradigm that involves identifying hazards associated with exposure to a chemical and developing quantitative dose-response information that, when combined with exposure information, is used to characterize risk and inform risk management decisions. Evaluating human health risk from exposure to mixtures rather than individual chemicals adds another level of complexity to this process. EPA’s Mixtures Guidance defines a chemical mixture as “any combination of two or more chemical substances regardless of source or of spatial or temporal proximity” and presents approaches for assessing the risks from chemical mixtures that depend on the nature of the available data. Information on the specific whole mixture of concern or a similar mixture are preferred, but frequently such data are not available. Component approaches are a third, commonly used option that allows for utilization of data on the individual components of a mixture in a process that is informed by what is known about the similarities of the mixture components. Further, a fraction-based approach consistent with EPA’s Mixtures Guidance addresses concerns regarding the effects of weathering and defines petroleum hydrocarbon fractions on the basis of expected transport in the environment and analytical methods used to identify and quantify such environmental contaminants. For petroleum hydrocarbon fractions, the fraction-based approach has been utilized to generate Provisional Peer-Reviewed Toxicity Values (PPRTVs), which are primarily derived for use by EPA’s Superfund Program. This presentation will provide an overview of approaches for estimating health risk from chemical mixtures with greater attention being given to hydrocarbon mixtures. Examples to be discussed in greater detail include estimating cancer risks from exposure to PAH mixtures using a component approach and use of a fraction approach for derivation of PPRTVs for complex mixtures of aliphatic and aromatic hydrocarbons. The views expressed in this presentation are those of the author and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency.

  • Friday, April 8, 2022

    11:00am - 12:00pm (PST)
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    Placental Barrier and Fetal Exposure to Mycoestrogens

    Lauren Aleksunes, Pharm.D, Ph.D
    Professor
    Rutgers University

    Exposure of babies to chemicals can increase the risk of disease later in life. This presentation will discuss factors that regulate the extent to which chemicals reach the baby through the placenta. Our research team is particularly interested in fungal-derived estrogenic toxins, known as mycoestrogens, that are present in the food supply and implicated in reproductive and developmental toxicities. 

  • Friday, March 4, 2022

    10:00 AM -12:00 PM
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    2022 PNWC-TEHR Pilot Project Ignite Talks

    TBA

    Applications for the Strategic Initiative Awards:

    1. Dr. Diana Rohlman (OSU) “Wildfire Smoke and Infant Health”
    2. Dr. Sarah Rothenberg (OSU) “Reducing Methylmercury Exposure through Fish Consumption in Lane County, Oregon”
    3. Dr. Manuel Garcia-Jaramillo (OSU) “Identification and Evaluation of Toxic Contaminant Mixtures in Surface Water from the Portland Harbor Superfund Site Using Effect-Directed Analysis Coupled to Non-target High-Resolution Mass Spectrometry”

     

    Applications for the Vanguard Awards:

    1. Dr. Veronica Irvin (OSU) “Development of a treatment decision aid for home environmental contaminants using a mobile approach”
    2. Dr. Siva Kolluri (OSU) “p27/Kip1 cell cycle inhibitor as an unexpected regulator of PAH toxicity”
    3. Dr. Lew Semprini (OSU) “Cometabolic Treatment of 1,2,3-Trichloropropane in Hydrogel Beads and the Evaluation of Toxicity Reduction Using Embryonic Zebrafish Assays”
    4. Dr. Karen Guillemin (UO) “Modulation of tissue iron by microbiota, inflammation, and environmental exposures”
    5. Dr. Susan Tilton (OSU) “Development of a 3D respiratory co-culture model for assessing toxicity to chemicals from wildfire smoke”
  • Friday, February 4, 2022

    11:00-12:00 PM
    Email shawn.tucker @ oregonstate.edu for zoom invite

    Rebalancing Agrochemical Cycles: From The Molecular To Systems Level

    Leanne Gilbertson, PhD
    Associate Professor of Environmental Engineering Fulton C. Noss Faculty Fellow
    University of Pittsburgh

    Immense agrochemical inputs, including pesticides and nutrients, are required for crop production and their use is incredibly inefficient. When considered at the global scale, these inefficiencies have tremendous economic and environmental consequences caused by emissions to the atmosphere (e.g., greenhouse gases) and surrounding water bodies (e.g., eutrophication). There are also massive losses of embodied resources and emissions when agrochemicals do not reach their target. As such, there is an opportunity for innovative solutions to have a big impact on an industry that is critical to the wellbeing of the global population. Yet, choices we make about the raw materials we use and how we design new technologies to increase performance have upstream (e.g., embodied resources) and downstream (e.g., emissions) implications. A combined approach that involves design decisions at the molecular level with systems-level analyses is necessary to preclude shifting burdens to other life cycle stages and to uncover high impact contributors across the life cycle. In this talk, I will discuss research from my group that aims at defining and addressing agrochemical use inefficiencies in crop production, including (i) evaluating tradeoffs of proposed nanotechnology solutions, (ii) sustainably designing carriers for delivering agrochemicals more efficiently to roots, and (iii) modeling nitrate transport and uptake in soil.   

  • Friday, January 7, 2022

    11:00am - 12:00pm (PST)
    zoom (email shawn.tucker @ oregonstate.edu for full info)

    Exosomes and extracellular vesicles in environmental toxicology – new approaches to assess the impact of environmental exposures on human health

    Andrea Baccarelli, MD PhD
    Chair and Professor of Environmental Health Sciences, Director, Precision Environmental Health Laboratory
    Director, P30 Center for Environmental Health in Northern Manhattan Columbia University Mailman School of Public Health, New York, NY

    My lab studies a cell-to-cell communication system that the body uses to maintain homeostasis. When environmental exposures disrupt homeostatic communication patterns, we seek to detect those shifts by “listening in” to the communications mediated by circulating extracellular vesicles (EVs). EVs are tiny (<1 µm) membrane-bound vesicles, which encompass exosomes, microvesicles, microparticles and other types of vesicles, released into the bloodstream by human cells and can be easily studied in blood samples. EVs contain cargo, such as non-coding RNAs, that can act on the recipient cell to modify it. My lab found overall patterns, based on the concentrations of EVs and their cargo, before disease develops. We also determined that EV-based communication is highly sensitive to environmental exposures. However, human data on EVs as a potential mediator of environmental toxicity are limited. I will present evidence from human environmental studies indicating that EV encapsulated miRNAs may mediate effects caused by toxic exposures. In these investigations, we have shown that exposures, including air pollution, BPA and other chemicals, strongly modify the EV-miRNA profiles. I will present data demonstrating that altered EV-miRNA profiles are associated with disease. Based on current evidence, I will propose possible models for the interplay between toxicants and EVs in human health and disease.

  • Friday, December 3, 2021

    3pm-5pm
    Zoom

    Environmental Chemical Impact on the Host-Microbiome Interaction

    Andrew D. Patterson, PhD
    Pennsylvania State University

    The field of toxicology has long suggested that host microbiota could influence the disposition and toxicity of environmental chemicals. Early correlative studies of heavy metal exposure identified the microbiota as contributing to host toxicity. However, technological limitations necessary for cataloging the microbiota community structure and for characterizing their metabolic capabilities have hitherto hindered progress in this area. Technological advances including sequence-based identification and functional characterization via mass spectrometry-based metabolite profiling have begun to shed light on how microbes influence and/or impact toxicity outcomes. Data will be presented to highlight key aspects of gut microbiota-host interaction and how environmental chemicals (dioxins, furans, polychlorinated biphenyls) can impact this important connection.

  • Friday, November 5, 2021

    1:00-2:00 PM
    Zoom

    The Silent Spring of Obesogens: Translational Mechanisms of Obesity Caused by DDT Exposure Across Lifetimes

    Michele A. La Merrill, PhD MPH
    Associate Professor of Department of Environmental Toxicology
    UC Davis

    Adult and prenatal exposures to the pesticide DDT and its metabolite DDE have been associated with risk of obesity in subsequent generations of people, mice and rats in numerous studies.  Our research indicates that these obesogenic effects are caused by impaired metabolism. We have observed that prenatal exposure to DDT or DDE impairs body heat production in mice from their first week of life to 9 months of age. Indeed, metabolic reductions in thermogenesis, the production of body heat, are associated not just with DDT and DDE exposures, but also with numerous pharmaceuticals and genes that are known to cause obesity. Epigenome studies in both mice and humans with DDT and DDE exposures have revealed extensive changes in DNA methylation enriching the thermogenesis pathway, including changes in DNA methylation of upstream signaling and substrate regulation pathways. Defects in the thermogenic function but not the structure of mouse brown adipose tissue and cultured brown adipocytes have observed. Additionally, prenatal DDT reduces the innervation of mouse brown adipose tissue, and the upstream synaptic connectivity is reduced by either DDT or DDE exposure prenatally. This body of research evidence indicates that both DDT and DDE act as obesogens by targeting both brown adipose and the sympathetic nervous system to impair thermogenesis.