• Friday, June 2, 2023

    11:00AM-12:00 PM
    Location: TBD (email shawn . tucker @ oregonstate . edu for zoom info)

    Identification of physiologic and dietary Ah receptor ligands key to understanding function

    Gary Perdew
    H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences
    Penn State
  • Friday, April 7, 2023

    12:00-1:00 PM
    Location: TBD

    A Fraction-Based Approach to Mixture Risk Evaluation: PPRTV Assessment for Complex Mixtures of Aliphatic and Aromatic Hydrocarbons

    Allison Phillips
    US Environmental Protection Agency (EPA)

    Total petroleum hydrocarbon (TPH) contamination is present at numerous Superfund sites across the nation. Hydrocarbon products are complex mixtures containing perhaps hundreds of hydrocarbon compounds and compositions vary among different products. Once released, the composition of a hydrocarbon product will change due to differential fate and transport of its components. To estimate the human health hazards and risk associated with TPH exposure at Superfund sites, a fraction-based approach was taken in the Provisional Peer Reviewed Toxicity Value (PPRTV) assessment of these complex mixtures. The TPH mixture was divided into 6 subfractions, defined based on structural attributes and further categorized by carbon and equivalent carbon ranges. The health risk of each fraction can be estimated using a variety mixture assessment approaches, including the indicator chemical method, surrogate mixture method, hazard index method, or relative potency factor method, with method selection driven by data availability. Fraction-specific hazard and risk estimates are then summed using either dose (noncancer) or response (cancer) addition to provide an estimate of mixture hazard or risk. Background on the PPRTV Program, mixture risk assessment methods, and an example calculation will be presented.

  • Friday, March 3, 2023

    11:00AM-12:00 PM
    Location: Linus Pauling Science Center, Room 402 and Zoom (Email Shawn Tucker for zoom info)

    2023 PNW-CTEHR Pilot Project Ignite Pitch Talks

    Pacific Northwest Center for Translational Environmental Health Research

    Applicants for the Pacific Northwest Center for Translational Environmental Health
    Pilot Project Program will be sharing their research ideas in short Ignite Pitches.
    This is a chance to learn about the state-of-the-art science, technology, and
    stakeholder engagement ideas being pursued by members in the Center and ask questions about their latest
    research ideas.

    Speakers: Each speaker has 6 minutes to share their ideas followed by 4 minutes for questions.

    The Oregon Human Microplastics Project: assessing microplastics exposure via intake and microbiome survey to identify potential impacts on health

    Susan Brander

    New Determinants of TCDD Signaling

    Siva Kolluri

    Cometabolic Treatment of 1,2,3-Trichloropropane in Hydrogel Beads and the Evaluation of Toxicity Reduction Using Embryonic Zebrafish Assays

    Lew Semprini

    Non-calcemic vitamin D-hydroxyderivative 20(OH)D3 as preventive agent against UV induced DNA damage and spontaneous melanoma

    Arup Indra

    Neurotoxic Signatures of Drinking Water Contaminants

    Manuel Garcia-Jaramillo
  • Friday, February 3, 2023

    12:00-1:00 PM
    Location: TBD

    Stephania Cormier

    Respiratory Immunology
    Louisiana State University A&M Medical Center
  • Friday, December 2, 2022

    11:00am - 12:00pm (PST)
    Location: Zoom

    ASP3IRE Center: Accelerating Research Translation For Children’s Environmental Health

    Molly Kile
    College of Public Health and Human Sciences
    Oregon State University

    Molly Kile is an environmental epidemiologist whose research focuses on understanding how exposures to chemicals influence human health. Her expertise is in conducting population-based environmental health studies and often works with communities that are disproportionately impacted by environmental pollutants. She received her doctoral degree from Harvard School of Public Health in 2006 and is currently a Professor at the College of Public Health and Human Sciences at Oregon State University. She is currently the PI on two active NIEHS-funded R01s that are studying the effects of flame retardants on children’s neurocognitive and behavioral growth and private well water stewardship. She is also interim deputy director of the Pacific Northwest Center for Translational Environmental Health Research (P30) and the co-PI of the newly formed ASPIRE Center at OSU (P2C) that is focusing on accelerating the adoption of evidence-based policies, programs, and practices that promote children’s environmental health.

  • Friday, October 7, 2022

    11:00am - 12:00pm (PST)
    Location: TBD

    Dysregulation Of Rna Metabolism In Arsenic Exposed Cells

    J. Christopher States Professor
    Department of Pharmacology and Toxicology University of Louisville

    Arsenic exposure is a global public health problem. Arsenic is a multi-organ toxicant and chronic exposure causes multiple chronic diseases including cancer. Skin cancer is the most common cancer caused by arsenic exposure but the mechanism(s) of carcinogenesis remain unclear. This presentation focuses on dysregulation of RNA metabolism in an in vitro model of skin carcinogenesis by chronic low level arsenic exposure. Dysregulated expression of microRNA and mRNAs and alternative mRNA splicing and the intersection with chromosomal instability will be discussed.

  • Friday, August 5, 2022

    1:00-2:00 PM
    Location: zoom (email shawn.tucker @ oregonstate.edu for full info)

    Amazon Prime for Inflammation - NLRP3 Inflammasome Activation Mechanism

    Reginald McNulty
    Assistant Professor
    Department of Molecular Biology and Biochemistry, The University of California Irvine

    The NLRP3 inflammasome has been identified as a key immune sensor for tissue damage. Although NLRP3 inflammasome assembly/activation leads to the production of inflammatory messengers (called cytokines) that alert the host immune system to initiate inflammatory responses, its dysregulation often results in overt diseases due to uncontrolled inflammation. Unfortunately, exposure to a number of environmental toxicants including PFAS have been shown to induce NLRP3 inflammasome activation that in turn initiates an undesirable inflammatory response, thereby causing numerous pathologies. Although stimulating agents have not been demonstrated to directly bind NLRP3, they are able to trigger mitochondrial damage and subsequent release of mitochondrial contents that somehow signal the activation of NLRP3 inflammasome. We seek to identify the mitochondrial ligand responsible for direct NLRP3 activation and probe the molecular determinants of recognition for this interaction.

  • Friday, July 1, 2022

    11:00am - 12:00pm (PST)
    Location: TBD

    Darryl Hood

    Ohio State University
  • Friday, June 3, 2022

    11:00am - 12:00pm (PST)
    Location: zoom (email shawn.tucker @ oregonstate.edu for full info)

    SBIR/STTR Opportunities Workshop


    11:00:00 AM: Introduction Robyn Tanguay
    11:05:00 AM: Basics of NIEHS SBIR and STTR programs NIEHS
           ES priority areas and success stories  
           Example Programs NIEHS  
           Basic Program Requirements  
    Company Example #1 (OSU Faculty member)  Steven O’Connell
    Company Example #2  Roarke Horstmeyer
           (Company working with OSU Faculty member)  Ramona Optics
    How can State of Oregon and OSU help?  Karl Mundorff
    Panel Discussion and Q/A  All


    Daniel T. Shaughnessy, Ph.D.
    Health Scientist Administrator
    Tel 984-287-3321
    [email protected]
    MyExposome, Inc.:
    Steven O'Connell, MS PhD
    Senior Scientist/Co-founder
    Corvallis, OR 97330
    Lingamanaidu V. Ravichandran, Ph.D.
    Health Scientist Administrator
    Tel 984-287-3309
    [email protected]
    Ramona Optics:
    Roarke Horstmeyer, PhD
    1000 W. Main St., Ste 2A
    Durham, NC 27701
    Karl Mundorff
    Executive Director of Innovation and Entrepreneurship, Director OSU Advantage
    [email protected]
  • Friday, May 6, 2022

    11:00am - 12:00pm (PST)
    Location: zoom (email shawn.tucker @ oregonstate.edu for full info)

    Basic Principles Of Human Health Risk Assessment For Environmental Chemical Mixtures With A Focus On Estimating Risks From Hydrocarbon Mixtures

    Margaret Pratt
    Center for Public Health and Environmental Assessment
    US EPA

    Chemical risk assessments follow a multistep paradigm that involves identifying hazards associated with exposure to a chemical and developing quantitative dose-response information that, when combined with exposure information, is used to characterize risk and inform risk management decisions. Evaluating human health risk from exposure to mixtures rather than individual chemicals adds another level of complexity to this process. EPA’s Mixtures Guidance defines a chemical mixture as “any combination of two or more chemical substances regardless of source or of spatial or temporal proximity” and presents approaches for assessing the risks from chemical mixtures that depend on the nature of the available data. Information on the specific whole mixture of concern or a similar mixture are preferred, but frequently such data are not available. Component approaches are a third, commonly used option that allows for utilization of data on the individual components of a mixture in a process that is informed by what is known about the similarities of the mixture components. Further, a fraction-based approach consistent with EPA’s Mixtures Guidance addresses concerns regarding the effects of weathering and defines petroleum hydrocarbon fractions on the basis of expected transport in the environment and analytical methods used to identify and quantify such environmental contaminants. For petroleum hydrocarbon fractions, the fraction-based approach has been utilized to generate Provisional Peer-Reviewed Toxicity Values (PPRTVs), which are primarily derived for use by EPA’s Superfund Program. This presentation will provide an overview of approaches for estimating health risk from chemical mixtures with greater attention being given to hydrocarbon mixtures. Examples to be discussed in greater detail include estimating cancer risks from exposure to PAH mixtures using a component approach and use of a fraction approach for derivation of PPRTVs for complex mixtures of aliphatic and aromatic hydrocarbons. The views expressed in this presentation are those of the author and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency.