The Aquatic Biomedical Models Facility Core is unique worldwide as a facility equipped to conduct biomedical research using zebrafish as aquatic research models. It primarily consists of a self-contained fish hatchery and histopathology complex for rearing fish and for conducting tumor and toxicity studies. For the carcinogenesis and toxicity studies, investigators can chose several exposure routes, such as water-bath exposure of embryos or fry, dietary exposure, or embryo injection.

The current zebrafish facility is composed of approximately 400 research tanks capable of holding up to 4,000 adult zebrafish for short and long-term studies. A significant expansion project is underway in which tank capacity will increase 10-fold. One of the unique advantages of zebrafish is the availability of hundreds of mutant and transgenic zebrafish with unique properties suited for specific experiments. This core allows our investigators access to any of these animals by providing a mechanism for their incorporation and propagation in the core. Currently, several wild-type zebrafish strains are maintained in the facility. In addition, a number of transgenic reporter lines are maintained which express GFP in specific cells and organs. In addition we have assembled the tools necessary to provide investigators access to transgenic approaches in zebrafish. Transient over expression (DNA and RNA) and antisense (modified oligonucleotides, morpholinos) repression technique are now routine.

Learn more about the facility and the robotic system on the SARL web page.

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